The Columbia University Diabetes and Endocrinology Research Center provides research support for investigators pursuing research on diabetes and metabolic disorders. The DERC provides a central support structure to foster collaboration among investigators working in the areas of diabetes, immunology, transplantation, obesity and arteriosclerosis/lipid research and supports their activities by providing shared core resources, funding for pilot/feasibility studies and a common intellectual environment.
DERC members have access to Core facilities to support their research activities. The Columbia DERC provides core services in four areas of research:
- Hormone & Metabolite
- Flow Cytometry
- Mouse Phenotyping
Core services are provided on a fee-for-service basis.
In addition, the DERC provides for financial support through the pilot/feasibility program. More importantly, the DERC is committed to supporting all members through program enrichment activities and scientific interactions to foster a collegial approach to diabetes research.
Pilot and Feasibility Program
The DRC funds P/F projects for up to $50,000/year. Projects are generally funded for a year, but can be extended for a second year, based on progress. The Pilot/feasibility program supports research projects related to diabetes. Three types of applications are considered:
- Proposals from young investigators who have not held any prior funding to carry out preliminary studies leading to an NIH, ADA or JDFR grant application;
- Proposals for innovative/high risk projects by established investigators in the field of diabetes;
- Proposals from established investigator, without prior funding in diabetes, who wish to undertake a diabetes- project.
Pilot Feasibility Grants
Animal Physiology & Phenotyping : Columbia University Mouse Phenotyping
DRC Mouse Phenotyping
The Mouse Phenotyping Core is organized around the three services Body Composition, Whole Body Metabolic Assessment and Metabolic Clamp.
Assay - Human & Laboratory Animal : Columbia University Hormone / Metabolite
The purpose of the Hormone/Metabolite Core Laboratory is to make available to DERC investigators a variety of analytical techniques that are of interest in the study of diabetes, atherosclerosis, obesity, insulin resistance and related problems... Flow Cytometry : Columbia University Flow Cytometry
The goal of the Flow Cytometry core facility is to aid DERC researchers in all aspects of Analytic Cytometry (cell surface markers, signaling, cytokines). To date, services have included caliber; cantoll; LSRII; BD influx flow sorting; and HLA.. Histology, Morphology & Image Analysis : Columbia Histopathology
The Histopathology Core is designed to assist DERC investigators in the histopathological characterization of metabolic tissues, such as muscle, liver, fat brain, pancreas, and gut, whose dysfunction can contribute to diabetes. The Core provides..
Center DirectorsDomenico Accili, M.D. :
Center Director and Director, Islet & Immunology Core 212-851-5332 Jeanine Albu, M.D. :
Associate Director, St. Luke's-Roosevelt Satellite 212-523-4183 Rudolph L. Leibel :
Associate Center Director, Director, Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Director of P&F and Enrichment Programs 212-851-5257
Center PeopleRaphael Clynes, M.D., Ph.D. :
Director, Flow Cytometry 212-305-5289 Anthony W. Ferrante, Jr., MD, PhD :
Director, Mouse Phenotyping Core 212-851-5322 Siu-hong Ho, Ph.D. :
Manager, Flow Cytometry 212-304-5649 Hongfeng Jiang :
Lipidomic Analysis Blandine Laferrère, MD :
Assistant Director, Hormone & Metabolite F. Xavier Pi-Sunyer, M.D., M.P.H. :
Director, Hormone and Metabolite Core 212-523-4161 Lori Sussel, Ph.D. :
Director, Histopathology Core 212-851-5115