There is a substantial genetic contribution for susceptibility to most common diseases, although for many of these diseases, specific DNA polymorphisms related to disease susceptibility have yet to be identified. My research program utilizes a variety of genetic epidemiologic methods to try to dissect the genetic and environmental determinants of a variety of complex diseases, including type-2 diabetes, cardiovascular disease, stroke, hypertension, osteoporosis and obesity. The goal of these efforts is to detect and identify common gene variants that may influence susceptibility to one or more of these disorders, and to determine how these variants may interact with other gene variants and/or with lifestyle factors to influence disease risk.

The bulk of our research is carried out in large population studies. For example, we work extensively with the Old Order Amish population of Lancaster County, Pennsylvania, in whom we are currently studying the genetics of diabetes, cardiovascular disease, hypertension, osteoporosis and longevity. The unique ancestral history of this population makes it exceptionally well-suited for studies of genetics. 

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