In some cases, additional preclinical testing is needed to validate potential therapies under disease-specific conditions and in multiple animal models before therapeutics can enter the T1D-RAID development pipeline. In recognition of this need, NIDDK recently established the Type 1 Diabetes Preclinical Testing Program (T1D-PTP) to provide investigators with access to the established facilities and expertise needed to extend, enhance and validate preclinical studies of promising new therapeutics. The T1D-PTP program currently supports two contracts, which are separate from each other and from the T1D-RAID NCI contract resources mentioned above, to assist in preclinical development of therapeutics for T1D:

• Agents to be tested for Preclinical Efficacy in Prevention or Reversal of Type 1 Diabetes in Rodent Models. Type 1 Diabetes Preclinical Testing Program (T1D-PTP) (NOT-DK-08-012)
• Testing for Preclinical Efficacy in Prevention or Reversal of Diabetic Complications in Rodent Models (NOT-DK-07-013)

The T1D-RAID and T1D-PTP are programs intended to remove the most common barriers to progress in identification and development of new therapies for Type 1 Diabetes. The common goal of these programs is to support and provide for the preclinical work necessary to obtain "proof of principle" establishing that a new molecule or novel approach will be a viable candidate for expanded clinical evaluation.