Penn Mouse Phenotyping, Physiology and Metabolism Core

Overview

The Mouse Phenotyping, Physiology and Metabolism Core provides investigators of the Penn Diabetes and Endocrinology Research Center (DRC) with access to state-of-the-art, timely and cost-effective resources for performing metabolic studies in mice.

Services

Organismal metabolism is regulated by a complex interplay between multiple organ systems, environment, and diet. We provide state of the art services, innovative techniques, and helpful consultation to both experienced and novice investigators with regards to metabolic questions.

Glucose homeostasis

• Clamp techniques
• Glucose tolerance test
• Insulin tolerance test
• Pyruvate tolerance test

Energy Homeostasis

• Energy expenditure
• Fatty acid oxidation
• Exercise testing

vivo metabolic labeling and flux

• Stable isotope infusion
• Enzyme kinetics
• Metabolic flux

Body composition

• NMR
• DEXA