Michael Olivier PhD

Dr. Olivier is Director of the Center for Precision Medicine, and Professor in the Department of Internal Medicine at Wake Forest School of Medicine. Prior to his current appointment, he was Chair of the Department of Genetics at the Texas Biomedical Research Institute in San Antonio, TX, and Professor of Physiology at the Biotechnology and Bioengineering Center at the Medical College of Wisconsin in Milwaukee, WI.

Dr. Olivier’s research focused initially on the analysis of the genetic basis of human obesity and related co-morbidities. Research in his group has focused on the development of novel approaches to functionally characterize human sequence variants. For the the past two decades, his laboratory has integrated genomics with mass spectrometry (proteomics, metabolomics) to advance our understanding of how disease-associated sequence variants affect normal cell and organ function in a wide range of human diseases.

My laboratory uses a wide range of genomics, proteomics, metabolomics and bioinformatics tools to study the molecular basis of common human diseases. We routinely use next generation sequencing, gene expression analysis, and mass spectrometry to profile cells and tissues from human patients and animal models to identify early molecular changes that happen in target tissues and organs during the initial development of diseases such as obesity, cardiovascular diseases, or dyslipidemias and fatty liver disease. Our group has been developing novel methodologies to functionally study human genome variation, and to help understand how mutations and sequence variants that have been identified in large scale genetic studies (e.g. genome-wide association studies) actually affect the normal function of cells. Work in our lab ranges from basic molecular biology to tissue culture, high-end sequencing and mass spectrometry, and computational data analysis.