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Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.

Citation
Wang, H., et al. “Admixture Mapping Identifies Novel Loci For Obstructive Sleep Apnea In Hispanic/Latino Americans.”. Human Molecular Genetics, pp. 675-687.
Center UCSD-UCLA University of Chicago
Multicenter
Multicenter
Author Heming Wang, Brian E Cade, Tamar Sofer, Scott A Sands, Han Chen, Sharon R Browning, Adrienne M Stilp, Tin L Louie, Timothy A Thornton, Craig Johnson, Jennifer E Below, Matthew P Conomos, Daniel S Evans, Sina A Gharib, Xiuqing Guo, Alexis C Wood, Hao Mei, Kristine Yaffe, Jose S Loredo, Alberto R Ramos, Elizabeth Barrett-Connor, Sonia Ancoli-Israel, Phyllis C Zee, Raanan Arens, Neomi A Shah, Kent D Taylor, Gregory J Tranah, Katie L Stone, Craig L Hanis, James G Wilson, Daniel J Gottlieb, Sanjay R Patel, Ken Rice, Wendy S Post, Jerome I Rotter, Shamil R Sunyaev, Jianwen Cai, Xihong Lin, Shaun M Purcell, Cathy C Laurie, Richa Saxena, Susan Redline, Xiaofeng Zhu
Abstract

Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Its prevalence and severity vary across ancestral background. Although OSA traits are heritable, few genetic associations have been identified. To identify genetic regions associated with OSA and improve statistical power, we applied admixture mapping on three primary OSA traits [the apnea hypopnea index (AHI), overnight average oxyhemoglobin saturation (SaO2) and percentage time SaO2 < 90%] and a secondary trait (respiratory event duration) in a Hispanic/Latino American population study of 11 575 individuals with significant variation in ancestral background. Linear mixed models were performed using previously inferred African, European and Amerindian local genetic ancestry markers. Global African ancestry was associated with a lower AHI, higher SaO2 and shorter event duration. Admixture mapping analysis of the primary OSA traits identified local African ancestry at the chromosomal region 2q37 as genome-wide significantly associated with AHI (P < 5.7 × 10-5), and European and Amerindian ancestries at 18q21 suggestively associated with both AHI and percentage time SaO2 < 90% (P < 10-3). Follow-up joint ancestry-SNP association analyses identified novel variants in ferrochelatase (FECH), significantly associated with AHI and percentage time SaO2 < 90% after adjusting for multiple tests (P < 8 × 10-6). These signals contributed to the admixture mapping associations and were replicated in independent cohorts. In this first admixture mapping study of OSA, novel associations with variants in the iron/heme metabolism pathway suggest a role for iron in influencing respiratory traits underlying OSA.

Year of Publication
2019
Journal
Human molecular genetics
Volume
28
Issue
4
Number of Pages
675-687
Date Published
12/2019
ISSN Number
1460-2083
DOI
10.1093/hmg/ddy387
Alternate Journal
Hum. Mol. Genet.
PMID
30403821
PMCID
PMC6360325
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