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Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.

Citation
Frikke-Schmidt, H., et al. “Weight Loss Independent Changes In Adipose Tissue Macrophage And T Cell Populations After Sleeve Gastrectomy In Mice.”. Molecular Metabolism, pp. 317-326.
Center University of Michigan
Featured
Author Henriette Frikke-Schmidt, Brian F Zamarron, Robert W O'Rourke, Darleen A Sandoval, Carey N Lumeng, Randy J Seeley
Keywords ATDC, ATM, Adipose tissue, Dendritic cells, FFA, HFS, macrophages, SVC, Sleeve gastrectomy, T cells, VSG, adipose tissue dendritic cell, adipose tissue macrophage, eWAT, epididymal white adipose tissue, free fatty acids, high fat sham, iWAT, inguinal white adipose tissue, stromal vascular cells, vertical sleeve gastrectomy
Abstract

OBJECTIVE: In addition to adipocytes, adipose tissue contains large numbers of immune cells. A wide range of evidence links the activity of these cells to regulation of adipocyte and systemic metabolic function. Bariatric surgery improves several aspects of metabolic derangements and at least some of these effects occur in a weight-loss independent manner. We sought to investigate the impact of vertical sleeve gastrectomy (VSG) on adipose immune cell frequencies.

METHODS: We analyzed the frequencies of immune cells within distinct adipose tissue depots in obese mice that had VSG or sham surgery with a portion of the latter group pair-fed such that their body mass was matched to the VSG animals.

RESULTS: We demonstrate that VSG induced a shift in the epididymal adipose tissue leukocyte profile including increased frequencies of CD11c macrophages, increased frequencies of T cells (CD4, CD8, and CD4/CD8 T cells all increased), but a significantly decreased frequency of adipose tissue dendritic cells (ATDC) that, despite the continued high fat feeding of the VSG group, dropped below control diet levels.

CONCLUSIONS: These results indicate that VSG induces substantial changes in the immune populations residing in the adipose depots independent of weight loss.

Year of Publication
2017
Journal
Molecular metabolism
Volume
6
Issue
4
Number of Pages
317-326
Date Published
12/2017
ISSN Number
2212-8778
DOI
10.1016/j.molmet.2017.02.004
Alternate Journal
Mol Metab
PMID
28377871
PMCID
PMC5369283
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