Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI.
| Citation | Gingerich, Morgan A, et al. “Clarifying the Function of Genes at the Chromosome 16p13 Locus in Type 1 Diabetes: CLEC16A and DEXI”. 2020. Genes and Immunity, vol. 21, no. 2, 2020, pp. 79–82. |
| Center | University of Michigan |
| Author | Morgan A Gingerich, Vaibhav Sidarala, Scott A Soleimanpour |
| Abstract |
More than a decade after the discovery of a novel type 1 diabetes risk locus on chromosome 16p13, there remains complexity and controversy over the specific gene(s) that regulate diabetes pathogenesis. A new study by Nieves-Bonilla et al. shows that one of these genes, DEXI, is unlikely to contribute to type 1 diabetes pathogenesis and positions the endolysosomal E3 ubiquitin ligase CLEC16A as the primary culprit by which this gene locus influences diabetes risk. |
| Year of Publication |
2020
|
| Journal |
Genes and immunity
|
| Volume |
21
|
| Issue |
2
|
| Number of Pages |
79-82
|
| Date Published |
12/2020
|
| ISSN Number |
1476-5470
|
| DOI |
10.1038/s41435-019-0087-7
|
| Alternate Journal |
Genes Immun.
|
| PMID |
31570815
|
| PMCID |
PMC7108966
|
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