The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity.
“The Contribution Of Transcriptional Coregulators In The Maintenance Of Β-Cell Function And Identity.”. Endocrinology..
|Author||Rebecca K Davidson, Sukrati Kanojia, Jason M Spaeth|
|Keywords||coregulator, islet, Transcription, β-cell function, β-cell identity|
Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity that disrupts gene expression programs essential for cell function and identity. TF activity is modulated by recruited coregulators that govern activation and/or repression of target gene expression, thereby providing a supporting layer of control. To date, more than 350 coregulators have been discovered that coordinate nucleosome rearrangements, modify histones, and physically bridge general transcriptional machinery to recruited TFs; however, relatively few have been attributed to β-cell function. Here, we will describe recent findings on those coregulators with direct roles in maintaining islet β-cell health and identity and discuss how disruption of coregulator activity is associated with diabetes pathogenesis.
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