The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity.

Citation
Davidson, R. K., et al. “The Contribution Of Transcriptional Coregulators In The Maintenance Of Β-Cell Function And Identity.”. Endocrinology.
Center Indiana University
Author Rebecca K Davidson, Sukrati Kanojia, Jason M Spaeth
Keywords coregulator, islet, Transcription, β-cell function, β-cell identity
Abstract

Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity that disrupts gene expression programs essential for cell function and identity. TF activity is modulated by recruited coregulators that govern activation and/or repression of target gene expression, thereby providing a supporting layer of control. To date, more than 350 coregulators have been discovered that coordinate nucleosome rearrangements, modify histones, and physically bridge general transcriptional machinery to recruited TFs; however, relatively few have been attributed to β-cell function. Here, we will describe recent findings on those coregulators with direct roles in maintaining islet β-cell health and identity and discuss how disruption of coregulator activity is associated with diabetes pathogenesis.

Year of Publication
2021
Journal
Endocrinology
Volume
162
Issue
2
Date Published
02/2021
ISSN Number
1945-7170
DOI
10.1210/endocr/bqaa213
Alternate Journal
Endocrinology
PMID
33211800
PMCID
PMC7749714