Endoplasmic Reticulum Protein Quality Control in β Cells.
| Citation | Shrestha, Neha, et al. “Endoplasmic Reticulum Protein Quality Control in β Cells”. 2020. Seminars in Cell & Developmental Biology, vol. 103, 2020, pp. 59–67. |
| Center | University of Michigan |
| Author | Neha Shrestha, Rachel B Reinert, Ling Qi |
| Keywords | ER, ER-phagy, ERAD, UPR, diabetes, β cells |
| Abstract |
Type 1 and type 2 diabetes are associated with loss of β cell function. Optimal β cell function is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the roles of ER protein quality-control mechanisms, including the unfolded protein response (UPR), autophagy (specifically ER-phagy) and ER-associated degradation (ERAD), in β cells. We propose that different quality control mechanisms may control different aspects of β cell biology (i.e. function, survival, and identity), thereby contributing to disease pathogenesis. |
| Year of Publication |
2020
|
| Journal |
Seminars in cell & developmental biology
|
| Volume |
103
|
| Number of Pages |
59-67
|
| Date Published |
12/2020
|
| ISSN Number |
1096-3634
|
| DOI |
10.1016/j.semcdb.2020.04.006
|
| Alternate Journal |
Semin Cell Dev Biol
|
| PMCID |
PMC7321887
|
| PMID |
32402517
|
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