Trajectories in estimated glomerular filtration rate in youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study.

Citation
Westreich, K. D., et al. “Trajectories In Estimated Glomerular Filtration Rate In Youth-Onset Type 1 And Type 2 Diabetes: The Search For Diabetes In Youth Study.”. Journal Of Diabetes And Its Complications, p. 107768.
Center University of Colorado Denver
Author Katherine D Westreich, Scott Isom, Jasmin Divers, Ralph D'Agostino, Jean M Lawrence, Roopa Kanakatti Shankar, Lawrence M Dolan, Giuseppina Imperatore, Dana Dabelea, Elizabeth J Mayer-Davis, Amy K Mottl
Keywords diabetes, Kidney, Longitudinal, trajectory, Youth, EGFR
Abstract

AIMS: We sought to characterize the direction and associated factors of eGFR change following diagnosis of youth-onset type 1 and type 2 diabetes.

METHODS: We assessed the direction of eGFR change at two visits (mean 6.6 years apart) in SEARCH, a longitudinal cohort study of youth-onset type 1 and type 2 diabetes. We used the CKiD equation to estimate GFR and categorized 'rising' and 'declining' eGFR as an annual change of ≥3 ml/min/1.73 m in either direction. Multivariable logistic regression evaluated factors associated with directional change in eGFR.

RESULTS: Estimated GFR declined in 23.8% and rose in 2.8% of participants with type 1 diabetes (N = 1225; baseline age 11.4 years), and declined in 18.1% and rose in 15.6% of participants with type 2 diabetes (N = 160; baseline age 15.0 years). Factors associated with rising and declining eGFR (versus stable) in both type 1 and type 2 diabetes included sex, age at diagnosis, baseline eGFR and difference in fasting glucose between study visits. Additional factors in type 1 diabetes included time from baseline visit, HbA1c and body mass index.

CONCLUSIONS: Over the first decade of diabetes, eGFR decline is more common in type 1 diabetes whereas eGFR rise is more common in type 2 diabetes.

Year of Publication
2021
Journal
Journal of diabetes and its complications
Volume
35
Issue
2
Number of Pages
107768
Date Published
02/2021
ISSN Number
1873-460X
DOI
10.1016/j.jdiacomp.2020.107768
Alternate Journal
J Diabetes Complications
PMID
33168393
PMCID
PMC7855388