Islet Regeneration: Endogenous and Exogenous Approaches.

Citation
Docherty, F. M., and L. Sussel. “Islet Regeneration: Endogenous And Exogenous Approaches.”. International Journal Of Molecular Sciences.
Center University of Colorado Denver
Author Fiona M Docherty, Lori Sussel
Keywords beta cell, diabetes, islet, pancreas, regeneration
Abstract

Both type 1 and type 2 diabetes are characterized by a progressive loss of beta cell mass that contributes to impaired glucose homeostasis. Although an optimal treatment option would be to simply replace the lost cells, it is now well established that unlike many other organs, the adult pancreas has limited regenerative potential. For this reason, significant research efforts are focusing on methods to induce beta cell proliferation (replication of existing beta cells), promote beta cell formation from alternative endogenous cell sources (neogenesis), and/or generate beta cells from pluripotent stem cells. In this article, we will review (i) endogenous mechanisms of beta cell regeneration during steady state, stress and disease; (ii) efforts to stimulate endogenous regeneration and transdifferentiation; and (iii) exogenous methods of beta cell generation and transplantation.

Year of Publication
2021
Journal
International journal of molecular sciences
Volume
22
Issue
7
Date Published
03/2021
ISSN Number
1422-0067
DOI
10.3390/ijms22073306
Alternate Journal
Int J Mol Sci
PMID
33804882