Islet Regeneration: Endogenous and Exogenous Approaches.
“Islet Regeneration: Endogenous And Exogenous Approaches.”. International Journal Of Molecular Sciences..
|Center||University of Colorado Denver|
|Author||Fiona M Docherty, Lori Sussel|
|Keywords||beta cell, diabetes, islet, pancreas, regeneration|
Both type 1 and type 2 diabetes are characterized by a progressive loss of beta cell mass that contributes to impaired glucose homeostasis. Although an optimal treatment option would be to simply replace the lost cells, it is now well established that unlike many other organs, the adult pancreas has limited regenerative potential. For this reason, significant research efforts are focusing on methods to induce beta cell proliferation (replication of existing beta cells), promote beta cell formation from alternative endogenous cell sources (neogenesis), and/or generate beta cells from pluripotent stem cells. In this article, we will review (i) endogenous mechanisms of beta cell regeneration during steady state, stress and disease; (ii) efforts to stimulate endogenous regeneration and transdifferentiation; and (iii) exogenous methods of beta cell generation and transplantation.
|Year of Publication||
International journal of molecular sciences
Int J Mol Sci