Adherence to Ketogenic and Mediterranean Study Diets in a Crossover Trial: The Keto-Med Randomized Trial.

Citation
Landry, M. J., et al. “Adherence To Ketogenic And Mediterranean Study Diets In A Crossover Trial: The Keto-Med Randomized Trial.”. Nutrients.
Center Stanford University
Author Matthew J Landry, Anthony Crimarco, Dalia Perelman, Lindsay R Durand, Christina Petlura, Lucia Aronica, Jennifer L Robinson, Sun H Kim, Christopher D Gardner
Keywords Mediterranean, crossover trial, diet adherence, dietary trial, ketogenic
Abstract

Adherence is a critical factor to consider when interpreting study results from randomized clinical trials (RCTs) comparing one diet to another, but it is frequently not reported by researchers. The purpose of this secondary analysis of the Keto-Med randomized trial was to provide a detailed examination and comparison of the adherence to the two study diets (Well Formulated Ketogenic Diet (WFKD) and Mediterranean Plus (Med-Plus)) under the two conditions: all food being provided (delivered) and all food being obtained by individual participants (self-provided). Diet was assessed at six time points including baseline (×1), week 4 of each phase when participants were receiving food deliveries (×2), week 12 of each phase when participants were preparing and providing food on their own (×2), and 12 weeks after participants completed both diet phases and were free to choose their own diet pattern (×1). The adherence scores for WFKD and Med-Plus were developed specifically for this study. Average adherence to the two diet patterns was very similar during both on-study time points of the intervention. Throughout the study, a wide range of adherence was observed among participants-for both diet types and during both the delivery phase and self-provided phase. Insight from this assessment of adherence may aid other researchers when answering the important question of how to improve behavioral adherence during dietary trials. This study is registered at clinicaltrials.gov NCT03810378.

Year of Publication
2021
Journal
Nutrients
Volume
13
Issue
3
Date Published
03/2021
ISSN Number
2072-6643
DOI
10.3390/nu13030967
Alternate Journal
Nutrients
PMID
33802709
PMCID
PMC8002540