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Chronic tissue inflammation and metabolic disease.

Citation
Lee, Y. S., and J. Olefsky. “Chronic Tissue Inflammation And Metabolic Disease.”. Genes & Development, pp. 307-328.
Center UCSD-UCLA
Author Yun Sok Lee, Jerrold Olefsky
Keywords glucose intolerance, immunometabolism, inflammation, Insulin resistance, Macrophage, Metaflammation, β-cell dysfunction
Abstract

Obesity is the most common cause of insulin resistance, and the current obesity epidemic is driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic, subacute tissue inflammation is a major etiologic component of the pathogenesis of insulin resistance and metabolic dysfunction in obesity. Here, we summarize recent advances in our understanding of immunometabolism. We discuss the characteristics of chronic inflammation in the major metabolic tissues and how obesity triggers these events, including a focus on the role of adipose tissue hypoxia and macrophage-derived exosomes. Last, we also review current and potential new therapeutic strategies based on immunomodulation.

Year of Publication
2021
Journal
Genes & development
Volume
35
Issue
5-6
Number of Pages
307-328
Date Published
03/2021
ISSN Number
1549-5477
DOI
10.1101/gad.346312.120
Alternate Journal
Genes Dev
PMID
33649162
PMCID
PMC7919414
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