The mission of the Physiology Core is to facilitate the use of model organisms in diabetes and metabolism-related research.
The Core provides:
- Access to a wide array of resources, technology, equipment and services for the generation and study of genetically modified mice and other model organisms;
- Consultation on experimental design and analysis;
- Technology development; and
- Opportunities for collaboration and training.
The Core offers:
- Distribution of genetically modified mice (MIP-GFP, MIP-Luc, MIP-CreER and others)
- Advice, training and service in metabolic phenotyping of mice (glucose and insulin tolerance testing, metabolic cage studies (TSE LabMaster Metabolism Research Platform), body composition by DEXA
- Advice, training and service in generating diabetic mouse models using streptozotocin and partial pancreatectomy
- Advice, training and service in islet transplantation into mice (intraportal and kidney capsule)
- Advice, training and service using imaging and image analysis for large-scale analysis of beta-cell mass, islet size distribution, islet cellular composition and islet vasculature of mouse, pig and human pancreas