Yale Diabetes Translational Core


The objective of the Diabetes Translational Research Core (DTRC) is to establish a core research staff with specialized expertise in the performance of complex clinical studies in diabetes and metabolism, and to provide training and education for the development of next generation of clinical researchers in diabetes.

Through its new Clinical and Translational Science Awards (CTSA), the NIH has undertaken a bold new program to redesign the clinical and translational research infrastructure to accelerate the translation of new scientific findings into health gains for the nation. The goals of the CTSA are well aligned with the mission of the DRC to improve the health of Americans with diabetes by translating basic discoveries into new strategies for the prevention, treatment and cure of diabetes.

In October 2006, Yale was selected as one of the initial 12 academic medical centers to receive a CTSA (P.I. R. Sherwin). Consequently, the Yale DRC is ideally positioned to benefit from the services and resources provided by the Yale CTSA. The partnership between the Yale DRC and the CTSA will allow the development of an integrated and efficient infrastructure to support diabetes research and clinical research education on a level not previously possible.


  • Specific Aim 1: To provide specialized clinical and translational research infrastructure (trained personnel, access to equipment, laboratory resources, research facilities) to help support complex metabolic studies.
  • Specific Aim 2: To establish a structured training and credentialing program in the conduct of a wide variety of metabolic research techniques (insulin-glucose clamps in outpatient research unit and magnetic resonance spectroscopy facility, stable isotope infusions, indirect calorimetry, VO2max testing, etc) for new investigators and research nursing staff.
  • Specific Aim 3: To assist with initiation and implementation of metabolic studies via protocol development, regulatory support, and recruitment of study participants. This component of the core will be CTSA supported.

Core People

Core Director
William V Tamborlane MD Yale Diabetes Translational Core Email