Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.
| Citation | Khosravi-Maharlooei, Mohsen, et al. “Rapid Thymectomy of NSG Mice to Analyze the Role of Native and Grafted Thymi in Humanized Mice”. 2020. European Journal of Immunology, vol. 50, no. 1, 2020, pp. 138–141. |
| Center | Columbia University |
| Author | Mohsen Khosravi-Maharlooei, Markus Hoelzl, Hao Wei Li, Rachel C Madley, Elizabeth E Waffarn, Nichole M Danzl, Megan Sykes |
| Keywords | Hematopoietic stem cells, humanized mice, NSG mice, Thymectomy, Thymopoiesis |
| Abstract |
We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafted thymic tissue in humanized mice. |
| Year of Publication |
2020
|
| Journal |
European journal of immunology
|
| Volume |
50
|
| Issue |
1
|
| Number of Pages |
138-141
|
| Date Published |
01/2020
|
| ISSN Number |
1521-4141
|
| DOI |
10.1002/eji.201948205
|
| Alternate Journal |
Eur. J. Immunol.
|
| PMID |
31583677
|
| PMCID |
PMC6940512
|
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