Developing Insulin Delivery Devices with Glucose Responsiveness.

Citation
Wang, Z., et al. “Developing Insulin Delivery Devices With Glucose Responsiveness.”. Trends In Pharmacological Sciences, pp. 31-44.
Center North Carolina
Author Zejun Wang, Jinqiang Wang, Anna R Kahkoska, John B Buse, Zhen Gu
Keywords diabetes treatment, drug delivery, glucose-responsive, insulin administration device
Abstract

Individuals with type 1 and advanced type 2 diabetes require daily insulin therapy to maintain blood glucose levels in normoglycemic ranges to prevent associated morbidity and mortality. Optimal insulin delivery should offer both precise dosing in response to real-time blood glucose levels as well as a feasible and low-burden administration route to promote long-term adherence. A series of glucose-responsive insulin delivery mechanisms and devices have been reported to increase patient compliance while mitigating the risk of hypoglycemia. This review discusses currently available insulin delivery devices, overviews recent developments towards the generation of glucose-responsive delivery systems, and provides commentary on the opportunities and barriers ahead regarding the integration and translation of current glucose-responsive insulin delivery designs.

Year of Publication
2021
Journal
Trends in pharmacological sciences
Volume
42
Issue
1
Number of Pages
31-44
Date Published
01/2021
ISSN Number
1873-3735
DOI
10.1016/j.tips.2020.11.002
Alternate Journal
Trends Pharmacol Sci
PMID
33250274
PMCID
PMC7758938