North Carolina

The mission of the North Carolina Diabetes Research Center (NCDRC) is to create and support an interactive regional diabetes research community (184 members) across four premiere research institutions in North Carolina, who currently garner over $70 million annually for support of their diabetes research:

  • Duke University (Duke)
  • The University of North Carolina at Chapel Hill (UNC)
  • Wake Forest School of Medicine (WF)
  • North Carolina A&T (NC A&T)

The North Carolina Diabetes Research Center will support Research Cores that represent unique strengths at each institution. These Cores will support studies of the current Research Base at each respective institution, but will also be made available to the other NCDRC institutions, where their use has been hampered by less easy access.

An expanded Pilot and Feasibility Program will encourage use of these now regional Cores, bring to the field new investigators and young scientists, and draw those not previously working in the field. We will leverage the existing infrastructure at each institution’s NIH Clinical and Translational Science Award (CTSA) site, to guide investigators to other resources that enhance their scientific productivity and efficiency.

The goal of the North Carolina Diabetes Research Center is to create connectivity in the diabetes research community, thereby fostering new advances in basic and translational diabetes research. We will take advantage of the substantial pre-existing resources and capabilities at each institution, and connect investigators to resources unique to each campus, to maximize the ability of member investigators – whether new investigators or scientists new to diabetes research – to answer important questions across the spectrum of translational approaches. There is a history of collaboration in diabetes research among the four institutions.

The Regional Core Resources to be directly supported by the NCDRC will include a Genomics and Proteomics Core, and a world-renowned Metabolomics Core, including not only a range of state-of-the-art analyses but equally importantly, interpretive services that are often a bottleneck for such resources.

Research Cores


Molecular Biology, Genetics & Genomics,
Protein, Proteomics, Metabolomics & Mass Spectrometry
North Carolina Genomics and Proteomics Core Michael Olivier PhD
The Genomics and Proteomics Core (GPC) will utilize state-of-the-art resources and expertise in genomics and mass spectrometry at the Wake Forest Center for Precision Medicine to provide unique access to high-throughput instrumentation and analytical expertise to NCDRC faculty and affiliate members in support of ongoing and future research programs.
Protein, Proteomics, Metabolomics & Mass Spectrometry
North Carolina Metabolomics Core Christopher B Newgard PhD
Comprehensive metabolic analysis, or “metabolomics”, is a technology that defines the chemical phenotype of living systems. Given that metabolic fluxes and metabolite levels are downstream of genomic, transcriptomic, and proteomic variability, metabolomics provides a highly integrated profile of biological status.
Protein, Proteomics, Metabolomics & Mass Spectrometry
North Carolina Metabolomics Core Deborah M Muoio Phd
Comprehensive metabolic analysis, or “metabolomics”, is a technology that defines the chemical phenotype of living systems. Given that metabolic fluxes and metabolite levels are downstream of genomic, transcriptomic, and proteomic variability, metabolomics provides a highly integrated profile of biological status.