Nrf2: The Master and Captain of Beta Cell Fate.

Citation
Baumel-Alterzon, S., et al. “Nrf2: The Master And Captain Of Beta Cell Fate.”. Trends In Endocrinology And Metabolism: Tem, pp. 7-19.
Center Albert Einstein College of Medicine
Author Sharon Baumel-Alterzon, Liora S Katz, Gabriel Brill, Adolfo Garcia-Ocaña, Donald K Scott
Keywords Nrf2, diabetes, Metabolic stress, oxidative stress, pancreatic beta cell, proliferation
Abstract

Prolonged hyperglycemia is toxic to pancreatic β cells, generating excessive reactive oxygen species, defective glucose-stimulated insulin secretion, decreased insulin production, and eventually β cell death and diabetes. Nrf2 is a master regulator of cellular responses to counteract dangerous levels of oxidative stress. Maintenance of β cell mass depends on Nrf2 to promote the survival, function, and proliferation of β cells. Indeed, Nrf2 activation decreases inflammation, increases insulin sensitivity, reduces body weight, and preserves β cell mass. Therefore, numerous pharmacological activators of Nrf2 are being tested in clinical trials for the treatment of diabetes and diabetic complications. Modulating Nrf2 activity in β cells is a promising therapeutic approach for the treatment of diabetes.

Year of Publication
2021
Journal
Trends in endocrinology and metabolism: TEM
Volume
32
Issue
1
Number of Pages
7-19
Date Published
01/2021
ISSN Number
1879-3061
DOI
10.1016/j.tem.2020.11.002
Alternate Journal
Trends Endocrinol Metab
PMID
33243626
PMCID
PMC7746592