Mark O Goodarzi MD PhD

The laboratory of Mark O. Goodarzi, MD, PhD, seeks to identify genetic factors underlying conditions related to insulin resistance and the metabolic syndrome, using a population genetic approach. A major focus area is elucidation of the genetic determinants of insulin clearance, via candidate gene and genome-wide association analyses. Other areas of interest include insulin resistance and atherosclerosis in Hispanics and the polycystic ovary syndrome. Epigenetic contributions to polycystic ovary syndrome are being explored via the study of DNA methylation of tissues isolated from prenatally androgenized animal models. Pharmacogenetic studies are focused on the glycemic response to statins. Another research effort is the phenotyping of insulin resistance by physiologic infusion studies.