University of Pennsylvania

University of Pennsylvania

Penn Diabetes Research Center
Smilow Center for Translational Research
3400 Civic Center Boulevard, 12th floor
Philadelphia, PA 19104
United States

Google Map
DRC Website
Center Director: Mitchell A Lazar MD PhD


The DRC participates in the nationwide inter-disciplinary program established over 40 years ago by the NIDDK to foster diabetes research. The Penn DRC is centered in the Smilow Center for Translational Research at the University of Pennsylvania Perelman School of Medicine, and serves over 120 diabetes-oriented investigators including many from other schools within the University of Pennsylvania as well as additional institutions from the mid-Atlantic region.

The Penn DRC is highly interactive and interdisciplinary, representing many basic science and clinical departments at Penn and the other institutions, and supports research in diabetes and obesity via Scientific Cores, a Pilot and Feasibility Grant Program, and a series of seminars, retreats, and other academic enrichment activities that facilitate communication, collaboration of DRC investigators in the pursuit of new understanding, treatment, and cures for diabetes, obesity, and related metabolic disorders.

The IDOM and DRC create a unique and exciting environment within a great university and prominent health system.

Partner Institutions

Research Cores

Animal Physiology & Phenotyping
Penn Mouse Phenotyping, Physiology and Metabolism CoreJoseph A Baur PhD
The Mouse Phenotyping, Physiology and Metabolism Core provides investigators of the Penn Diabetes and Endocrinology Research Center with access to state-of-the-art, timely and cost-effective resources for performing metabolic studies in mice.
Assay - Human & Laboratory Animal
Penn Radioimmunoassay and Biomarkers CoreMichael Rickels MD MS
The Radioimmunoassay and Biomarkers Core offers a large number of high quality immunoassay services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research.
Islet Biology & Metabolism
Penn Pancreatic Islet Cell Biology CoreDoris A Stoffers MD PhD
The Islet Cell Biology Core provides DRC members with state of the art support including experimental design, islet isolation, and performance of and/or training in an expansive range of assays for physiological and morphometric assessment of pancreatic islet function and growth.
Molecular Biology, Genetics & Genomics
Penn Functional Genomics CoreKlaus Kaestner PhD
The FGC provides state-of-the-art experiment planning, sample preparation, quality assessment, library construction, DNA sequencing, and data analysis services to DRC members.
Molecular Biology, Genetics & Genomics
Penn Viral Vector CoreJulie Johnston PhD
The main objective of the Viral Vector Core is to provide DRC center members access to state- of-the-art vector technology for preclinical studies.
Protein, Proteomics, Metabolomics & Mass Spectrometry
Princeton Metabolomics CoreJoshua D Rabinowitz MD PhD
One of the core aims of the Metabolomics Core is to develop and validate metabolomic methods and data analysis software, including flux analysis.
Specialized Animal & Gene Modification
Penn Transgenic and Chimeric Mouse CoreStephen A Liebhaber MD
The Transgenic and Chimeric Mouse Core has generated a wide range of transgenic and gene-targeted mouse lines that have proven to be powerful tools for the study of the molecular biology and physiology of Type I and Type II diabetes.