The NIDDK Information Network (dkNET), is a search portal and information hub that helps researchers find research resources and data repositories relevant to their research and keep up to date on new tools, services and mandates to support robust and reproducible science, including funding opportunities, resource authentication and data sharing. Research resources include reagents, organisms, software tools, databases and services.
The Accelerating Medicines Partnership (AMP) is a public-private partnership between the National Institutes of Health (NIH), the U.S. Food and Drug Administration (FDA), 10 biopharmaceutical companies and multiple non-profit organizations to transform the current model for developing new diagnostics and treatments by jointly identifying and validating promising biological targets for therapeutics. The ultimate goal is to increase the number of new diagnostics and therapies for patients and reduce the time and cost of developing them.
The centers that make up the ACE program conduct clinical trials and basic research on new immune-based therapies for autoimmune diseases. This program is designed to enhance interactions between scientists and clinicians in order to accelerate the translation of research findings into medical applications.
A centralized facility established to provide genotyping and statistical genetics services for investigators seeking to identify genes that contribute to human disease. CIDR concentrates primarily on multifactorial hereditary disease although linage analysis of single gene disorders can also be accommodated.
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.
The Common Metabolic Diseases Knowledge Portal enables browsing, searching, and analysis of human genetic information linked to common metabolic diseases and traits, while protecting the integrity and confidentiality of the underlying data.
The mission of the Autoimmune Disease Prevention Centers is to engage in scientific discovery which significantly advances knowledge for the prevention and regulation of autoimmune disease.
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to provide an environment that will foster communication and collaboration between investigator communities involved in complications research.
The Digestive Diseases Research Core Centers (DDRCCs) and Digestive Diseases Research Development Centers (DDRDCs) coordinate and foster interdisciplinary cooperation between groups of established investigators who conduct programs of high quality research that are related to a common theme in digestive diseases research.
To promote research on the causes of drug-induced liver disease, the National Institute of Diabetes and Digestive and Kidney Diseases has created the Drug-Induced Liver Injury Network (DILIN). Its purpose is to collect and carefully analyze cases of liver problems caused by prescription drugs and alternative medicines, such as herbal products.
The fundamental aim of GoKinD is to facilitate investigator-driven research into the genetic basis of diabetic nephropathy by collecting, storing, and distributing genetic samples from cases and controls of type 1 diabetes and diabetic nephropathy.
HIRN’s mission is to better understand how human beta cells are lost in Type 1 Diabetes and to find innovative strategies to protect or replace functional beta cell mass in diabetic patients. HIRN was established in 2014 to help organize and support collaborative research related to the loss of functional beta cell mass in Type 1 Diabetes (T1D). The project consists of four independent research initiatives: CBDS, CHIB, CMAI and CTAR.
Human Pancreas Analysis Program (HPAP) is performing deep phenotyping of the human endocrine pancreas and its interaction with the immune system, to better understand the cellular and molecular events that precede and lead to the beta cell loss in Type-1 Diabetes (T1D). The National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) supports HPAP through multiple NIH grants.
The ITN is an international consortium of scientists and physicians dedicated to the clinical evaluation of novel tolerogenic approaches for the treatment of autoimmune diseases, asthma and allergic diseases, and the prevention of graft rejection.
The IIDP mission is to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and translational medicine. Pivotal to IIDP’s mission is providing reliable, high quality resources to the research community from industry-leading Islet Isolation Centers (IICs).
The goal of the International Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene by generating and systematically phenotyping 20,000 knockout mouse strains. The IMPC is generating a knockout mouse strain for every protein coding gene by using the embryonic stem cell resource generated by the International Knockout Mouse Consortium (IKMC).
The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice.
Our mission is to advance medical and biological research by providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders. The six Centers are housed at outstanding academic institutions, staffed by experts in state-of-the-art technology. Researchers can ship mice to one of the Centers and obtain on a fee-for-service basis a range of complex exams used to characterize mouse metabolism and blood composition.
The MMRRC distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. The MMRRC is supported by the National Center for Research Resources at the National Institutes of Health.
The NHPCSG, a multi-institution consortium, was established to evaluate the safety and efficacy of novel donor-specific, tolerance induction therapies in non-human primate (NHP) models of kidney and islet transplantation.
The Nutrition Obesity Research Centers offer state-of-the art technologies and resources to a broad spectrum of investigators who are pursuing studies in nutrition, obesity and other related research areas. Each Center offers unique services that are geared towards facilitating basic, clinical, and translational research.
The Pediatric Acute Liver Failure (PALF) Study is the first multi-center, multi-national collaborative study aimed at identifying, characterizing, and developing management strategies for infants, children, and adolescents who present with acute liver failure.
(Re)Building a Kidney is an NIDDK-funded consortium of research projects working to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and their integration into complex structures that replicate human kidney function. Our ultimate goal is to coordinate and integrate research to support the development and implementation of strategies such as de novo repair of nephrons, the re-generation of nephrons, and the in vitro engineering of a biological kidney to enhance renal repair and promote the generation of new nephrons in the postnatal organ.