Boston Area

The Boston Area Diabetes Endocrinology Research Center (BADERC) is a consortium of laboratory-based and clinical investigators whose efforts are directed toward addressing many of the major research questions bearing on the etiology, pathogenesis, treatment and cure of type 1 and type 2 diabetes, and their associated microvascular and atherosclerotic complications.

The center Director (Joseph Avruch and Associates Directors (Joel F. Habener and Brian Seed) are highly productive senior investigators of international stature in signal transduction, gene expression, molecular biology and immunology, topics central to advances in diabetes research.

The participating scientists are based at a large number of Boston-area research institutions, primarily the major Harvard Medical School-affiliated teaching hospitals (the Massachusetts General Hospital, the Brigham and Women’s Hospital, the Beth Israel-Deaconess Medical Center) and the Boston University Medical Center, as well as several at the Harvard School of Arts and Sciences and other Harvard-affiliated research institutions (School of Public Health, the Dana-Farber Cancer center, the Scheppens Eye Research Institute), the New England Medical Center and the Massachusetts Institute of Technology.

These investigators are working at the cutting edge of fields most relevant to defining the pathogenesis and optimal treatment of type 1 and type 2 diabetes: The molecular and genetic basis of insulin action and insulin resistance; the biology of the vascular system and beta cell; the immunologic basis and optimal therapies for autoimmunity and transplant rejection; the development of new methods for glycemic monitoring and control.

The BADERC offers these scientists an array of core support services (Molecular Biology; Cell Biology & Morphology; Transgenics; Radioimmunoassay and Monoclonal antibody generation; Fluorescent activated cell sorting and Metabolic Physiology) that incorporate the latest technical advances in molecular genetics, cell biology, and metabolic physiology provided by acknowledged experts. Most cores are heavily oriented towards hands-on training. Considerable expansion and upgrading of these services has occurred over the prior award period, and the utilization of these cost-effective, high quality support services has been robust. A new Proteomics core is proposed, poised to service both laboratory-based and clinical investigators./p>

The BADERC also sponsors a highly competitive program of pilot and feasibility grants. The availability of cost effective support services of outstanding quality together with the educational and pilot grants program has catalyzed new programs and collaborations, and attracted to diabetes research new talent from this outstanding scientific community. a goal of the center to foster the closest interactions between the laboratory based and clinical scientists, so as to ensure the translation of research discoveries into advances in the care of diabetic patients.

Research Cores

Animal Physiology & Phenotyping
Boston Area Metabolic Physiology Core Barbara Kahn MD
The Boston Area Metabolic Physiology Core provides consulting and teaching, use of DEXA scanner for determination of body fat and/or bone density, and use of Coulter Counter to measure cell number and cell size distribution.
Histology, Morphology & Imaging
Boston Area Cell Biology and Morphology Core Dennis Brown PhD
The Microscopy Core provides technical services and help for morphological studies and immunocytochemical work at the light (e. g., immunofluorescence) and the electron microscopic (e. g., immunogold) levels.
Islet Biology & Metabolism
Boston Area Pancreatic Islet Core James F Markmann MD PhD
The purpose of Pancreatic Islet Isolation Core of Boston Area Diabetes Endocrinology Research Center (BADRC) is to provide high quality islets to the local diabetes research community.
Specialized Animal & Gene Modification
Boston Area Transgenic Core Bradford Lowell MD PhD
The Transgenic Core generates transgenic and gene knockout mouse models relevant to obesity, diabetes and nutrition research. The Core also provides consultation on all aspects of making transgenic and gene knockout mice.